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KL101

Chemical Structure : KL101

CAS No.: 396721-89-4

KL101 (KL 101)

Catalog No.: PC-49458Not For Human Use, Lab Use Only.

KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1).
KL101 showed selectivity over CRY2, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.

Physicochemical Properties

M.Wt 377.506
Formula C22H23N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethylbenzamide

References

1. Miller S, et al. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2026191118.

2. Miller S, et al. Nat Chem Biol. 2020 Jun;16(6):676-685.

3. Iida M, et al. J Biochem. 2022 May 11;171(5):501-507.

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