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Chemical Structure : KR-33028
Catalog No.: PC-35053Not For Human Use, Lab Use Only.
KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM.
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KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM; significantly decreases hypoxia-induced necrotic cell death and apoptotic cell death in H9c2 cells at 1-10 uM, significantly inhibits hypoxia-induced increases in cytosolic and mitochondrial Ca2+ level and cytochrome c release, and recovered hypoxia-induced Delta psi(m) reduction; demonstrates potent cardioprotective effects with minimal toxicity in perfused rat hearts.
| M.Wt | 244.272 | |
| Formula | C11H8N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jung YS, et al. Eur J Pharmacol. 2006 Mar 27;535(1-3):220-7.
2. Kim J, et al. Eur J Pharmacol. 2007 Jul 12;567(1-2):131-8.
3. Kim H, et al. Arch Pharm Res. 2005 Nov;28(11):1287-92.
4. Lee BK, et al. Brain Res. 2009 Jan 12;1248:22-30.
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