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Chemical Structure : KRN-633
CAS No.: 286370-15-8
Catalog No.: PC-42875Not For Human Use, Lab Use Only.
KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $115 | In stock | |
| 50 mg | $275 | In stock | |
| 100 mg | $435 | In stock | |
| 500 mg | Get quote |
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KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM; does not inhibits the phosphorylation of FGFR-1, EGFR, or c-Met at 10 uM; blocks the activation of mitogen-activated protein kinases by VEGF, inhibits VEGF-driven proliferation of HUVECs with IC50 of 14.9 nM; inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats.
Solid Tumors
Phase 1 Clinical
| M.Wt | 416.8582 | |
| Formula | C20H21ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl- |
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1. Matsunaga N, et al. Mol Cancer Ther. 2006 Jan;5(1):80-8.
2. Wada Y, et al. J Pharmacol Sci. 2010;112(3):290-8.
3. Morita A, et al. Exp Eye Res. 2014 Mar;120:127-37.
4. Nakamura K, et al. Mol Cancer Ther. 2004 Dec;3(12):1639-49.
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