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Chemical Structure : KSP-IA
Catalog No.: PC-70049Not For Human Use, Lab Use Only.
A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM.
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A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM; has no ihibitory activity toward other kinesins, includin CENP-E, MKLP-1, KIF-3A, and uKHC (IC50>50 uM); induces the formation of monoastral spindles, causes mitotic arrest in a dose-dependent manner (EC50=30 nM) in A2780 ovarian carcinoma cells; sustained KSP inhibition activates the proapoptotic protein, Bax, and both activation of the spindle checkpoint and subsequent mitotic slippage are required for Bax activation.
| M.Wt | 356.417 | |
| Formula | C21H22F2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tao W, et al. Cancer Cell. 2005 Jul;8(1):49-59.
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