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KT-474

Chemical Structure : KT-474

CAS No.: 2432995-68-9

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KT-474 (SAR444656, KT474, KT 474)

Catalog No.: PC-20693Not For Human Use, Lab Use Only.

KT-474 (SAR444656, KT474) is a potent, highly selective, orally bioavailable IRAK4 degrader for the treatment of IL-1R/TLR-driven conditions and diseases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KT-474 (SAR444656, KT474) is a potent, highly selective, orally bioavailable IRAK4 degrader for the treatment of IL-1R/TLR-driven conditions and diseases.

    Physicochemical Properties

    M.Wt 865.94
    Formula C44H49F2N11O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-((S)-2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

    References

    1. Ackerman L, et al. Nat Med. 2023 Dec;29(12):3127-3136.

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