Chemical Structure : KTX207
CAS No.:
3075021-91-6
KTX207
(KTX-207)
Catalog No.: PC-24472Not For Human Use, Lab Use Only.
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively.
KTX207 is highly selective for PDE4 shortforms over longforms.
KTX207 degrades PDE4D shortform with high selectivity at sub-nanomolar concentration via the ubiquitin-proteasomal system
KTX207 is more effective at increasing cAMP levels than conventional inhibitor BI 1015550.
KTX207 can suppress cancer cell growth in 2D and 3D cultures of A549 cells.
Physicochemical Properties
|
M.Wt
|
882.14
|
|
Formula
|
C47H63N9O6S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-(5-(1-(9-((2-(1-((S)-4-((1-(hydroxymethyl)cyclobutyl)amino)-5-oxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)piperidin-4-yl)pyrimidin-5-yl)oxy)nonyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
|
References
1. Sin YY. Et al. FEBS J. 2024 Dec 13. doi: 10.1111/febs.17359.
Contact Us
sales@probechem.com
