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Chemical Structure : KVD900
CAS No.: 1933514-13-6
Catalog No.: PC-73138Not For Human Use, Lab Use Only.
Sebetralstat (KVD900) is a potent,selective, competitive and reversible inhibitor of human plasma kallikrein (PKa) enzyme with Ki of 3.02 nM.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 25 mg | $598 | In stock | |
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| 1 g | Get quote |
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Sebetralstat (KVD900) is a potent,selective, competitive and reversible inhibitor of human plasma kallikrein (PKa) enzyme with Ki of 3.02 nM.
Sebetralstat (KVD900) inhibits dextran sulphate (DXS)-stimulated PKa enzyme activity and HK cleavage and reduced plasma prekallikrein and Factor XII activation in plasma.
Sebetralstat (KVD900) is a fast-acting oral PKa inhibitor that rapidly inhibits PKa activity, kallikrein kinin system activation and kininogen (HK) cleavage in plasma. shows a potential on-demand treatment for hereditary angioedema (HAE).
| M.Wt | 477.496 | |
| Formula | C25H24FN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (4.8 mg/mL) |
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| Chemical Name/SMILES |
N-((3-fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-(4-((2-oxopyridin-1(2H)-yl)methyl)phenyl)-1H-pyrazole-4-carboxamide |
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1. Duckworth EJ, et al. Clin Exp Allergy. 2022 Mar 12. doi: 10.1111/cea.14122.
2. Maetzel A, et al. J Allergy Clin Immunol. 2022 Jan 20:S0091-6749(21)02666-X.
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