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Chemical Structure : KW3902
Catalog No.: PC-61328Not For Human Use, Lab Use Only.
Rolofylline (KW3902) is a potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
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Rolofylline (KW3902) is a potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
Rolofylline (KW3902) displays 290-fold selectivity over A2AR.
Rolofylline (KW3902) antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).
| M.Wt | 356.46 | |
| Formula | C20H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6.
2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.
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