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Chemical Structure : KYP-2047
CAS No.: 796874-99-2
Catalog No.: PC-38478Not For Human Use, Lab Use Only.
KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | $988 | In stock | |
| 100 mg | $988 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.
KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.
KYP-2047 reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain in animal models of Parkinson's disease.
KYP-2047 also reduced tongue squamous cell-carcinoma (TSCC) cell viability at 50 and 100 uM, significantly reduced tumor burden and tumor weight, decreasing also angiogenesis markers VEGF and eNOS.
| M.Wt | 339.44 | |
| Formula | C20H25N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile |
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1. Jalkanen AJ, et al. Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):443-51.
2. Jalkanen AJ, et al. Neurosci Lett. 2011 Sep 15;502(2):107-11.
3. Myöhänen TT, et al. Br J Pharmacol. 2012 Jun;166(3):1097-113.
4. Scuderi SA, et al. Oncotarget. 2021 Dec 7;12(25):2459-2473.
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