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Chemical Structure : Karyostatin 1A
Catalog No.: PC-21347Not For Human Use, Lab Use Only.
Karyostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway.
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Karyostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway.
Karyostatin 1A specifically inhibit importin α/β mediated nuclear import in living cells.
Karyostatin 1A disrupts the binding of importin β to RanGTP.
| M.Wt | 971.22 | |
| Formula | C53H70N12O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martin Hintersteiner, et al. ACS Chem Biol. 2010 Oct 15;5(10):967-79.
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