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Chemical Structure : L-257
Catalog No.: PC-36015Not For Human Use, Lab Use Only.
L-257 (DDAH-1 inhibitor L-257) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM, Ki of 13 uM.
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L-257 (DDAH-1 inhibitor L-257) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM, Ki of 13 uM.
L-257 shows no direct inhibitory activity against NO synthase or effects on endothelium-denuded vessels.
L-257 impairs vascular homeostasis, improves survival, haemodynamics and organ function in experimental septic shock.
| M.Wt | 232.284 | |
| Formula | C9H20N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nandi M, et al. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2589-97.
2. Wang Z, et al. Biochem J. 2014 Jun 1;460(2):309-16.
3. Rossiter S, et al. J Med Chem. 2005 Jul 14;48(14):4670-8.
4. Leiper J, et al. Nat Med. 2007 Feb;13(2):198-203.
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