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Chemical Structure : L189
CAS No.: 64232-83-3
Catalog No.: PC-38571Not For Human Use, Lab Use Only.
L189 is a small moelcule DNA ligase I, III and IV inhibitor with IC50 of 5, 9 and 5 uM, blocks DNA ligase I DNA binding activity with Ki of 5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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L189 is a small moelcule DNA ligase I, III and IV inhibitor with IC50 of 5, 9 and 5 uM, blocks DNA ligase I DNA binding activity with Ki of 5 uM.
L189 preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ).
L189 significantly sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
| M.Wt | 246.3 | |
| Formula | C11H10N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone |
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1. Chen X, et al. Cancer Res. 2008 May 1;68(9):3169-77.
2. Timothy R L Howes, et al. DNA Repair (Amst). 2017 Dec;60:29-39.
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