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Chemical Structure : L6H21
Catalog No.: PC-21724Not For Human Use, Lab Use Only.
L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.
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L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.
L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages with IC50 of 6.58 and 8.59 μM, respectively.
L6H21 inhibits EtOH + LPS-induced apoptosis and mitochondrial damage in RAW264.7 cells.
L6H21 attenuates EtOH + LPS-induced ROS formation and TLR4–NF-κB activation, and decreases NLRP3 inflammasome activation.
L6H21 (10 mg/kg, Oral gavage, daily) effectively inhibits EtOH + LPS-induced hepatic fat accumulation, hepatic steatosis and liver injury in vivo.
| M.Wt | 298.34 | |
| Formula | C18H18O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kong X, et al. Alcohol Clin Exp Res. 2019 Aug;43(8):1662-1671.
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