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Chemical Structure : L82-G17
CAS No.: 92285-87-5
Catalog No.: PC-38570Not For Human Use, Lab Use Only.
L82-G17 is a selective, uncompetitive inhibitor of DNA ligase I, inhibits the third step of the ligation reaction, phosphodiester bond formation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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L82-G17 is a selective, uncompetitive inhibitor of DNA ligase I, inhibits the third step of the ligation reaction, phosphodiester bond formation.
L82-G17 did not inhibit LigIV.
L82-G17 exhibited increased activity against and selectivity for LigI compared with L82.
Cells lacking nuclear LigIIIα, which can substitute for LigI in DNA replication, were also more sensitive to L82-G17 than isogenic parental cells.
| M.Wt | 264.67 | |
| Formula | C11H9ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Hydroxybenzaldehyde 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone |
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1. Timothy R L Howes, et al. DNA Repair (Amst). 2017 Dec;60:29-39.
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