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Chemical Structure : LB-102
Catalog No.: PC-70155Not For Human Use, Lab Use Only.
LB-102 (LB-1.2, LB 102) is a potent, selective serine/threonine protein phosphatase 2A (PP2A) inhibitor with IC50 of 0.4 uM.
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LB-102 (LB-1.2, LB 102) is a potent, selective serine/threonine protein phosphatase 2A (PP2A) inhibitor with IC50 of 0.4 uM.
LB-102 displays more specificity than PP1 (IC50=80 uM).
LB-102 shows dose-dependant inhibition of GBM cell growth (IC50=5 uM).
LB-102 activates Plk-1 and Akt-1 and decreases p53 abundance in tumor cells.
LB-102 causes complete regression of GBM xenografts and neuroblastoma xenografts combined with TMZ.
| M.Wt | 354.403 | |
| Formula | C17H26N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lu J, et al. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11697-702.
2. Westermarck J, et al. Trends Mol Med. 2008 Apr;14(4):152-60.
3. Kovach JS, et al. Patent Cooperation Treat Appl WO/2008/097561.
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