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LC-1028

Chemical Structure : LC-1028

CAS No.: 2324158-08-7

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LC-1028 (LC1028, LC 1028)

Catalog No.: PC-36136Not For Human Use, Lab Use Only.

LC-1028 (LC1028) is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein, VCP), remains essentially irreversible aciivity against p97 mutant C522A.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LC-1028 (LC1028) is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein, VCP), remains essentially irreversible aciivity against p97 mutant C522A.

    Physicochemical Properties

    M.Wt 449.558
    Formula C28H27N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-(4-(Benzylamino)-5,6,7,8-tetrahydroquinazolin-2-yl)-2-methyl-1H-indol-4-yl)but-2-ynamide

    References

    1. Ding R, et al. J Med Chem. 2019 Mar 14;62(5):2814-2829.

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