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Chemical Structure : LCL521
Catalog No.: PC-38779Not For Human Use, Lab Use Only.
LCL521 is a small molecular inhibitor of acid ceramidase (ACDase), a lysosomotropic inhibitor with anticancer activity.
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LCL521 is a small molecular inhibitor of acid ceramidase (ACDase), a lysosomotropic inhibitor with anticancer activity.
LCL521 targets lysosomes and increases total cellular C16 ceramide level, significantly decreased myeloid-derived suppressor cell (MDSC) accumulation in vivo.
LCL521 enhances the direct tumor cell killing effect of photodynamic therapy (PDT) treatment.
| M.Wt | 592.778 | |
| Formula | C31H52N4O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bai A, et al. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.
2. Korbelik M, et al. Int J Cancer. 2016 Sep 15;139(6):1372-8.
3. Liu F, et al. Oncotarget. 2016 Dec 20;7(51):83907-83925.
4. Bai A, et al. PLoS One. 2017 Jun 14;12(6):e0177805.
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