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Chemical Structure : LCS3
CAS No.: 109844-92-0
Catalog No.: PC-72885Not For Human Use, Lab Use Only.
LCS3 is a small molecule that selectively impairs the growth of human lung adenocarcinoma (LUAD) cells, induces oxidative stress, inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively.
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|---|---|---|---|
| 25 mg | $598 | In stock | |
| 100 mg | $958 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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LCS3 is a small molecule that selectively impairs the growth of human lung adenocarcinoma (LUAD) cells, induces oxidative stress, inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively.
LCS3 selectively inhibited the growth of 24/25 NSCLC cell lines at low micromolar concentrations (CI50<5 uM), but not the non-transformed lung cell lines (IC50>10 uM).
LCS3 induces ROS and NRF2 pathway activation in sensitive LUAD cells.
LCS3 inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively, inhibits GSR through a reversible, uncompetitive mechanism.
LCS3 induces synergistic inhibition of the glutathione and thioredoxin pathways.
| M.Wt | 266.637 | |
| Formula | C11H7ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide |
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1. Fraser D Johnson, et al. Cell Rep. 2022 Feb 8;38(6):110343.
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