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Chemical Structure : LDC7559
CAS No.: 2407782-01-6
Catalog No.: PC-38284Not For Human Use, Lab Use Only.
LDC7559 is a small molecule that efficiently blocks NET formation and GSDMD-mediated pyroptotic cell death in human cells, also is an inhibitor of NOX2-dependent NETosis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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LDC7559 is a small molecule that efficiently blocks NET formation and GSDMD-mediated pyroptotic cell death in human cells, also is an inhibitor of NOX2-dependent NETosis.
LDC7559 inhibits NETosis independent of GSDMD but elicit identical phenotypes in neutrophils.
LDC7559 inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL).
| M.Wt | 349.39 | |
| Formula | C20H19N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(2-Methoxyphenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide |
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1. Neri Amara, et al. Cell. 2021 Aug 19;184(17):4480-4494.e15.
2. Gabriel Sollberger, et al. Sci Immunol. 2018 Aug 24;3(26):eaar6689.
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