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Chemical Structure : LDC8201
Catalog No.: PC-38640Not For Human Use, Lab Use Only.
LDC8201 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.
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LDC8201 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.
LDC8201 demonstrated tumor shrinkage in mice engrafted with patient-derived EGFR-H773_V774insNPH mutant cells
| M.Wt | 486.016 | |
| Formula | C28H28ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jonas Lategahn, et al. J Med Chem. 2022 Apr 29. doi: 10.1021/acs.jmedchem.1c02080.
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