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Chemical Structure : LGD-6972
Catalog No.: PC-43093Not For Human Use, Lab Use Only.
LGD-6972 (RVT 1502) is a novel potent, selective, orally bioavailable glucagon receptor (GCGR) antagonist.
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LGD-6972 (RVT 1502) is a novel potent, selective, orally bioavailable glucagon receptor (GCGR) antagonist; binds competitively to GCGR with high affinity and selectivity, suppressing both cAMP and glucose production in vitro; reduces acute glucagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models in vivo.
Diabetes
Phase 2 Clinical
| M.Wt | 702.9008 | |
| Formula | C43H46N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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1. Vajda EG, et al. Diabetes Obes Metab. 2017 Jan;19(1):24-32.
2. Vajda EG, et al. Diabetes. 2012;61(suppl 1):A252. Abstract.
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