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Chemical Structure : LL-K8-22
Catalog No.: PC-20323Not For Human Use, Lab Use Only.
LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins.
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LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins.
LL-K8-22 showed enhanced anti-proliferative effects over its parental molecule BI-1347.
LL-K8-22 exhibited more pronounced effects on CDK8–cyclin C downstream signaling than BI-1347, suppressing STAT1 phosphorylation more persistently.
LL-K8-22 inhibited E2F- and MYC-driven carcinogenic transcriptional programs.
| M.Wt | 573.79 | |
| Formula | C37H43N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mingyu Wang, et al. J Med Chem. 2023 Mar 17. doi: 10.1021/acs.jmedchem.2c02045.
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