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Chemical Structure : LM22A-4
CAS No.: 37988-18-4
Catalog No.: PC-61680Not For Human Use, Lab Use Only.
LM22A-4 is a small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not other Trks or p75(NTR).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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LM22A-4 is a small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not other Trks or p75(NTR).
LM22A-4 prevents neuronal degeneration with efficacy equal to that of BDNF in vitro models of neurodegenerative disease.
LM22A-4 causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.
LM22A-4 reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.
| M.Wt | 339.34 | |
| Formula | C15H21N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
50 mM in DMSO; 100 mM in H2O |
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| Chemical Name/SMILES |
N1,N3,N5-tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide |
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1. Simmons DA, et al. J Neurosci. 2013 Nov 27;33(48):18712-27.
2. Massa SM, et al. J Clin Invest. 2010 May;120(5):1774-85.
3. Kajiya M, et al. Int Immunopharmacol. 2014 Apr;19(2):245-52.
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