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LMPTP inhibitor 23 dihydrochloride

Chemical Structure : LMPTP inhibitor 23 dihydrochloride

CAS No.: 2310135-46-5

LMPTP inhibitor 23 dihydrochloride

Catalog No.: PC-21977Not For Human Use, Lab Use Only.

LMPTP inhibitor 23 dihydrochloride is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM.

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Biological Activity

LMPTP inhibitor 23 dihydrochloride is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM.
LMPTP inhibitor 23 displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B.
LMPTP inhibitor 23 inhibits uncompetitively LMPTP with Ki of 846 nM.
LMPTP inhibitor 23 substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss.

Physicochemical Properties

M.Wt 517.54
Formula C28H38Cl2N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N-diethyl-4-(4-((3-(piperidin-1-yl)propyl)amino)quinolin-2-yl)benzamide dihydrochloride

References

1. Stanford SM, et al. Nat Chem Biol. 2017 Jun;13(6):624-632.

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