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Chemical Structure : LOC1886
Catalog No.: PC-49542Not For Human Use, Lab Use Only.
LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4.
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LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4.
| M.Wt | 241.250 | |
| Formula | C13H11N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu H, et al. Cell Chem Biol. 2022 Dec 15;29(12):1680-1693.e9.
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