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Chemical Structure : LP-184
Catalog No.: PC-22197Not For Human Use, Lab Use Only.
LP-184 is an acylfulvene alkylating agent, inhibits viability of multiple GBM cell isolates including temozolomide-resistant and MGMT-expressing cells with IC50 of 22-310 nM.
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LP-184 is an acylfulvene alkylating agent, inhibits viability of multiple GBM cell isolates including temozolomide-resistant and MGMT-expressing cells with IC50 of 22-310 nM.
LP-184 demonstrated highly potent anticancer activity both in primary NSCLC cell lines and in those originating from brain metastases of primary lung cancers.
LP-184 activity correlated with PTGR1 transcript levels but was independent of mutations in key oncogenes (KRAS and KEAP1) and tumor suppressors (TP53 and STK11).
LP-184 was orders of magnitude more potent in vitro than cisplatin and pemetrexed.
LP-184 is an acylfulvene-derived prodrug activated by the oxidoreductase PTGR1 that alkylates at N3-adenine.
| M.Wt | 304.35 | |
| Formula | C16H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kulkarni A, et al. Cancer Res Commun. 2024 Apr 17. doi: 10.1158/2767-9764.CRC-23-0554.
2. Lal B, et al. Clin Cancer Res. 2023 Oct 13;29(20):4209-4218.
3. Kulkarni A, et al. Oncotarget. 2021 Apr 13;12(8):791-806.
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