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LP-935509

Chemical Structure : LP-935509

CAS No.: 1454555-29-3

LP-935509 (LP935509;LP 935509)

Catalog No.: PC-60635Not For Human Use, Lab Use Only.

LP-935509 is a potent, selective and brain-penetrant adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 of 3.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LP-935509 is a potent, selective and brain-penetrant adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 of 3.3 nM.
LP-935509 inhibited μ2 protein phosphorylation in HEK293 cells overexpressing human AAK1 with IC50 of 2.8 nM.
LP-935509 also potent inhibits closely related BIKE and GAK with IC50 of 14 nM and 320 nM, respectively in a panel of 389 kinases.
LP-935509 reduces pain response in phase II formalin and reverses fully established pain behavior in vivo.

Physicochemical Properties

M.Wt 396.451
Formula C20H24N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

isopropyl 4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

References

1. Kostich W, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

2. Louis JV, et al. Neuropharmacology. 2017 May 15;118:167-174.

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