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Request The Product List ofAP2-associated Kinase 1 (AAK1) AP2-associated Kinase 1 (AAK1)

Cat. No. Product Name CAS No. Information
PC-60637

BMS-901715

1699861-37-4

BMS-901715 is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor.

PC-60636

BMT-090605

1551403-51-0

BMT-090605 (BMT 090605, BMT090605) is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM; weakly inhibits BIKE and GAK with IC50 of 45 and 60 nM, respectively.

PC-60635

LP-935509

1454555-29-3

LP-935509 is a potent, selective and brain-penetrant adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 of 3.3 nM; inhibited μ2 protein phosphorylation in HEK293 cells overexpressing human AAK1 with IC50 of 2.8 nM; also potent inhibits closely related BIKE and GAK with IC50 of 14 nM and 320 nM, respectively in a panel of 389 kinases; reduces pain response in phase II formalin and reverses fully established pain behavior in vivo.

PC-35098

BMT-046091

1551401-20-7 BMT-046091 (BMT046091) is a potent and selective AAK1 inhibitor with IC50 of 2.8 nM; BMT-046091 is inactive in a panel of functional or binding assays for receptors, transporters and enzymes at >5 μM; [3H]BMT-046091 is a potent and selective radioligand to determine AAK1 distribution and target engagement.

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