Chemical Structure : LRPPRC inhibitor 3o
CAS No.:
LRPPRC inhibitor 3o
(LRPPRC-IN-1)
Catalog No.: PC-27294Not For Human Use, Lab Use Only.
LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation.
LRPPRC inhibitor 3o downregulates downstream OXPHOS subunits and ATP synthase, elicits broad antiproliferative effects in refractory and drug-resistant A549, BXPC-3, and NCI-H1975 cells (IC50=0.27-1.39 uM).
LRPPRC inhibitor 3o achieved tumor growth inhibition (TGI) rates of 73 and 49% with favorable safety profiles in PC9 and HCT116 xenografts.
Physicochemical Properties
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M.Wt
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574.15
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Formula
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C21H13Br2F3N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-3-hydroxy-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-carbohydrazide
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References
1. Ren H, et al. J Med Chem. 2026 Jul 13. doi: 10.1021/acs.jmedchem.6c00936.
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