Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LSP1-2111
Catalog No.: PC-62982Not For Human Use, Lab Use Only.
LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively; displays 25-, and 30-fold preference over mGlu7 and mGlu8 receptors; selectively inhibits striatopallidal GABAergic transmission with no effect at a synapse modulated solely by the mGlu7 and mGlu8 receptors; counteracts haloperidol-induced catalepsy in experimental parkinson model.
| M.Wt | 364.247 | |
| Formula | C12H17N2O9P | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Cajina M, et al. ACS Med Chem Lett. 2013 Dec 12;5(2):119-23.
2. Wierońska JM, et al. Neuropharmacology. 2010 Dec;59(7-8):627-34.
3. Wierońska JM, et al. Psychopharmacology (Berl). 2013 Jun;227(4):711-25.
4. Beurrier C, et al. FASEB J. 2009 Oct;23(10):3619-28.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
