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LT052

Chemical Structure : LT052

CAS No.: 2543545-44-2

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LT052 (LT-052, LT 052)

Catalog No.: PC-21331Not For Human Use, Lab Use Only.

LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2.
LT052 mediates BRD4/NF-κB/NLRP3 signaling inflammatory pathways with comparable protein expression and significantly improves symptoms of gout arthritis in a rat model.

Physicochemical Properties

M.Wt 449.49
Formula C22H19N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenesulfonamide, N-[1,2-dihydro-1-methyl-4-(4-methyl-1H-imidazol-1-yl)-2-oxopyrrolo[4,3,2-de]quinolin-6-yl]-2-methoxy-

References

1. Fei Jiang, et al. J Med Chem. 2019 Dec 26;62(24):11080-11107.

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