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Chemical Structure : LX2761
Catalog No.: PC-60689Not For Human Use, Lab Use Only.
A potent, locally acting and orally bioavailable SGLT1 inhibitor that inhibits human SGLT1- and SGLT2-mediated glucose uptake with IC50 of 2.2 nM and 2.7 nM, respectively, restricted to the intestinal lumen.
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A potent, locally acting and orally bioavailable SGLT1 inhibitor that inhibits human SGLT1- and SGLT2-mediated glucose uptake with IC50 of 2.2 nM and 2.7 nM, respectively, restricted to the intestinal lumen; synergistically increases active GLP-1 levels combined with sitagliptin, lowers postprandial glucose, fasting glucose, and hemoglobin A1C, and increased plasma total GLP-1 in mice; delays intestinal glucose absorption in vivo to improve glycemic control.
Diabetes
Phase 1 Clinical
| M.Wt | 601.803 | |
| Formula | C32H47N3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goodwin NC, et al. J Med Chem. 2017 Jan 26;60(2):710-721.
2. Powell DR, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):85-97.
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