Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LXRβ agonist CL2-57
Catalog No.: PC-49757Not For Human Use, Lab Use Only.
LXRβ agonist CL2-57 is a non-lipogenic ABCA1 inducer and an LXRβ-selective agonist (EC50=1.3 uM) and PPAR/RXR antagonist.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LXRβ agonist CL2-57 is a non-lipogenic ABCA1 inducer and an LXRβ-selective agonist (EC50=1.3 uM) and PPAR/RXR antagonist.
CL2-57 enhances ABCA1-linked luciferase activity in HepG2 liver cells (Emax=250%; EC50=1.8 uM).
CL2-57 selectively induces ABCA1 and lessens inflammation in vitro, CL2-57 dose-dependently increased cholesterol efflux from macrophages to apoA1, the primary acceptor of cholesterol from ABCA1 in vivo.
CL2-57 (10 mg/kg oral gavage) enhances glucose tolerance and insulin sensitivity in mice fed a high-fat diet (HFD).
CL2-57 reduces HFD-induced adiposity and alterations in liver gene expression, also reduces gluconeogenic metabolite, broadly attenuated pro-inflammatory cytokines, enzymes, and metabolites in HFD mice.
| M.Wt | 539.01 | |
| Formula | C23H23ClN2O7S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Cutler T Lewandowski, et al. EBioMedicine. 2021 Apr;66:103287.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
