Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LY-341495
CAS No.: 201943-63-7
Catalog No.: PC-45947Not For Human Use, Lab Use Only.
LY-341495 (LY341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LY-341495 (LY341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively.
LY-341495 shows less effectively blocks mGluR8 and mGluR7 (IC50=173 and 990 nM) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 uM).
LY-341495 penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.
| M.Wt | 353.3686 | |
| Formula | C20H19NO5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
9H-Xanthene-9-propanoic acid, .alpha.-amino-.alpha.-[(1S,2S)-2-carboxycyclopropyl]-, (.alpha.S)- |
|
1. Collado I, et al. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2849-54.
2. Schaffhauser H, et al. Mol Pharmacol. 1998 Feb;53(2):228-33.
3. Chung DS, et al. J Pharmacol Exp Ther. 1997 Nov;283(2):742-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
