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Chemical Structure : LY-3537982
CAS No.: 2414198-64-2
Catalog No.: PC-72313Not For Human Use, Lab Use Only.
LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM).
LY-3537982 does not inhibit growth of KRAS G12S/G13C/G12D mutant cells and WT KRAS cells (CI50>10 uM).
LY-3537982 displays high selectivity for proteome-wide cysteine residues was evaluated using competitive chemical proteomics (8866 peptides).
LY3537982 inhibits the growth of subcutaneous EL3187 NSCLC PDX tumors in nude mice in a dose dependent manner.
LY3537982 demonstrates robust tumor regression in combination with other agents in KRAS G12C in vivo models.
LY3537982 is a promising KRAS G12C inhibitor predicted to deliver >90% KRAS G12C target occupancy in the clinic.
| M.Wt | 500.905 | |
| Formula | C23H15ClF2N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(2-acryloyl-9-chloro-7-fluoro-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[f]imidazo[5,1-c][1,4]oxazepin-8-yl)-2-amino-7-fluorobenzo[b]thiophene-3-carbonitrile |
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