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Chemical Structure : LY3023414
CAS No.: 1386874-06-1
Catalog No.: PC-43082Not For Human Use, Lab Use Only.
LY3023414 is a potent, dual PI3K/mTOR inhibitor with IC50 of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 165 nM and 4.24 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTOR and DNA-PK, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LY3023414 is a potent, dual PI3K/mTOR inhibitor with IC50 of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 165 nM and 4.24 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTOR and DNA-PK, respectively.
LY3023414 inhibits the phosphorylation of AKT at position T308 with IC50 of 106 nM in the PTEN-deficient U87 MG glioblastoma cell line, inhibits phosphorylation of AKT at position S473 (IC50=94.2 nM) by mTORC2 as well as phosphorylation of mTORC1 kinase targets p70S6K (position T389; IC50=10.6 nM).
LY3023414 causes G1 cell-cycle arrest and shows broad antiproliferative activity in cancer cell panel screens.
LY3023414 exhibits antitumor activity in multiple xenograft models.
| M.Wt | 406.4775 | |
| Formula | C23H26N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Imidazo[4,5-c]quinolin-2-one, 1,3-dihydro-8-[5-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(2S)-2-methoxypropyl]-3-methyl- |
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1. Smith MC, et al. Mol Cancer Ther. 2016 Oct;15(10):2344-2356.
2. Zaidi AH, et al. Ann Surg. 2017 Jul;266(1):91-98.
3. Wei L, et al. Oncotarget. 2016 Nov 22;7(47):76374-76389.
4. Zheng L, et al. Oncotarget. 2017 Oct 27;8(58):98964-98973.
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