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Chemical Structure : LY344864
CAS No.: 186544-26-3
Catalog No.: PC-49006Not For Human Use, Lab Use Only.
LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $558 | In stock | |
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LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites.
LY344864 inhibited forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors with EC50 of 3 nM.
Oral and intravenous LY344864 administration potently inhibited dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats.
LY 344864 decreased the number of capsaicin-induced c-fos-like immunoreactive cells within trigeminal nucleus caudalis (ID50=0.6 mg/kg).
| M.Wt | 351.425 | |
| Formula | C21H22FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide |
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1. Phebus LA, et al. Life Sci. 1997;61(21):2117-26.
2. Mitsikostas DD, et al. Eur J Pharmacol. 1999 Mar 26;369(3):271-7.
3. Cohen ML, et al. J Pharmacol Exp Ther. 1999 Sep;290(3):935-9.
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