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Chemical Structure : LZFPN-90
Catalog No.: PC-22010Not For Human Use, Lab Use Only.
LZFPN-90 (LZ90) is a potent, dual NAMPT/PD-L1 targeting inhibitor with IC50 of 13 nM/28 nM for PD-1/PD-L1 and NAMPT, respectively.
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LZFPN-90 (LZ90) is a potent, dual NAMPT/PD-L1 targeting inhibitor with IC50 of 13 nM/28 nM for PD-1/PD-L1 and NAMPT, respectively.
LZFPN-90 treatment (0-20 uM) resulted in a concentration-dependent reduction in the NAD+ content in A2780 cells, also reduced NAD+ content in tumor tissues in vivo.
LZFPN-90 could inhibit cancer cell proliferation, arrest the cell cycle in the G2/M phase, and promote apoptosis by inhibiting NAMPT activity.
LZFPN-90 could promote T-cell proliferation, activate CD8+ toxic T cells, and enhance the secretion of IFN-γ and GzmB, thereby killing tumor cells.
LZFPN-90 (20 mg/kg, 40 mg/kg, i.p.) inhibits tumor growth in double-target overexpressed xenograft models and organoids.
LZFPN-90 exerts antitumor effects dependent on NAMPT and PD-L1 in the LLC OE NAMPT/PD-L1 mouse model.
| M.Wt | 608.77 | |
| Formula | C33H36N8O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yuan Yang, et al. EMBO Mol Med. 2024 Mar 6. doi: 10.1038/s44321-024-00051-z.
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