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Chemical Structure : Ladarixin sodium
Catalog No.: PC-61475Not For Human Use, Lab Use Only.
A novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM.
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A novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM; prevents PMN infiltration and tissue damage in several models of IR injury in vivo; abrogates motility and induces apoptosis in cultured cutaneous and uveal melanoma cells and xenografts; also prevents inflammation-mediated damage in MLD-STZ, prevents and reverses diabetes in NOD mice.
Diabetes
Phase 2 Clinical
| M.Wt | 397.315 | |
| Formula | C11H11F3NNaO6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Garau A, et al. Eur Cytokine Netw. 2006 Mar;17(1):35-41.
2. Citro A, et al. Diabetes. 2015 Apr;64(4):1329-40.
3. Kemp DM, et al. Oncotarget. 2017 Feb 28;8(9):14428-14442.
4. Bertini R, et al. Br J Pharmacol. 2012 Jan;165(2):436-54.
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