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Chemical Structure : Lazertinib
CAS No.: 1903008-80-9
Catalog No.: PC-60519Not For Human Use, Lab Use Only.
Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 200 mg | $798 | In stock | |
| 1 g | Get quote |
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Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.
Lazertinib shows the beneficial for the NSCLC with brain metastasis.
| M.Wt | 554.66 | |
| Formula | C30H34N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide |
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1. Patent US20160102076 A1.
2. Yun J, et al. Clin Cancer Res. 2019 Jan 22. pii: clincanres.2906.2018. doi: 10.1158/1078-0432.CCR-18-2906.
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