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Chemical Structure : Lenalidomide
CAS No.: 191732-72-6
Catalog No.: PC-20467Not For Human Use, Lab Use Only.
Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue for PROTAC design, Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN), and causes selective ubiquitination and degradation of IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $128 | In stock | |
| 500 mg | $198 | In stock | |
| 1 g | $298 | In stock | |
| 5 g | Get quote |
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Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue for PROTAC design, Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN), and causes selective ubiquitination and degradation of IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase.
Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.
Lenalidomide (CC-5013) inhibits production of pro inflammatory cytokines TNF-α, IL-1, IL-6, IL-12 and elevates the production of anti-inflammatory cytokine IL-10 from human PBMCs.
Lenalidomide (CC-5013) downregulates the production of IL-6 directly and also by inhibiting multiple myeloma (MM) cells and bone marrow stromal cells (BMSC) interaction.
Orally administered lenalidomide (250 mg/kg per day) reduces vascularization and total microvascular length in a rat mesenteric window assay.
| M.Wt | 259.27 | |
| Formula | C13H13N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- |
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1. Krönke J, et al. Oncoimmunology. 2014 Jul 3;3(7):e941742.
2. Kotla V, et al. J Hematol Oncol. 2009 Aug 12;2:36.
3. Lopez-Girona A, et al. Leukemia. 2012 Nov;26(11):2326-35.
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