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Linopirdine

Chemical Structure : Linopirdine

CAS No.: 105431-72-9

Linopirdine (DUP-996;Linopirine)

Catalog No.: PC-63067Not For Human Use, Lab Use Only.

Linopirdine (DUP-996, Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Linopirdine (DUP-996, Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.
Linopirdine blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
Linopirdine inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.

Physicochemical Properties

M.Wt 391.465
Formula C26H21N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one

References

1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.

2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.

3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

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