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Chemical Structure : Linopirdine dihydrochloride
CAS No.: 113168-57-3
Catalog No.: PC-63068Not For Human Use, Lab Use Only.
Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.
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Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker.
Linopirdine blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
Linopirdine inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.
| M.Wt | 464.39 | |
| Formula | C26H21N3O.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one |
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1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.
2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.
3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
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