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Chemical Structure : Lipofermata
CAS No.: 297180-15-5
Catalog No.: PC-35366Not For Human Use, Lab Use Only.
Lipofermata (CB16.2 aka) is a specific fatty acid transport (FATP) inhibitor, blocks human FATP2-mediated fatty acid uptake (IC50=4.84 uM in Caco-2 cells) without impacting other cellular functions.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Lipofermata (CB16.2 aka) is a specific fatty acid transport (FATP) inhibitor, blocks human FATP2-mediated fatty acid uptake (IC50=4.84 uM in Caco-2 cells) without impacting other cellular functions.
Lipofermata demonstrates cellualr transport inhibition activity models for myocytes (mmC2C12), pancreatic β-cells (rnINS-1E), intestinal epithelial cells (hsCaco-2), and hepatocytes (hsHepG2), as well as primary human adipocytes, which is specific for long and very long chain fatty acids but has no effect on medium chain fatty acids (C6-C10).
Lipofermata also abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.
| M.Wt | 360.229 | |
| Formula | C15H10BrN3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-bromo-5'-phenylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-one |
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1. Ahowesso C, et al. Biochem Pharmacol. 2015 Nov 1;98(1):167-81.
2. Black PN, et al. Medchemcomm. 2016 Apr 1;7(4):612-622.
3. Zhang M, et al. Cancer Discov. 2018 Jun 14. pii: CD-17-1371.
4. Sandoval A, et al. Biochem Pharmacol. 2010 Apr 1;79(7):990-9.
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