You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-Ferroptosis-Liproxstatin-1
Liproxstatin-1

Chemical Structure : Liproxstatin-1

CAS No.: 950455-15-9

Liproxstatin-1 (Liproxstatin 1)

Catalog No.: PC-43164Not For Human Use, Lab Use Only.

Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis.

Packing Price Stock Quantity
5 mg $98 In stock
10 mg $148 In stock
25 mg $248 In stock
50 mg $348 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis.
Liproxstatin-1 prevents BODIPY 581/591 C11 oxidation in Gpx4−/− cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis.
Liproxstatin-1 suppresses ferroptosis in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.

Physicochemical Properties

M.Wt 340.8499
Formula C19H21ClN4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-

References

1. Friedmann Angeli JP, et al. Nat Cell Biol. 2014 Dec;16(12):1180-91.

2. Kim SE, et la. Nat Nanotechnol. 2016 Nov;11(11):977-985.

3. Zilka O, et al. ACS Cent Sci. 2017 Mar 22;3(3):232-243.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: