Catalog No.: PC-27673Not For Human Use, Lab Use Only.
Litronesib ((R)-Litronesib, LY2523355) is a potent, selective and allosteric inhibitor of mitosis-specific kinesin Eg5 (Kif11, Kinesin Spindle Protein, KSP), inhibits microtubule (MT)-stimulated Eg5 ATPase activity with IC50 of 26 nM.
Litronesib ((R)-Litronesib, LY2523355) is a potent, selective and allosteric inhibitor of mitosis-specific kinesin Eg5 (Kif11, Kinesin Spindle Protein, KSP), inhibits microtubule (MT)-stimulated Eg5 ATPase activity with IC50 of 26 nM.
Litronesib ((R)-Litronesib, LY2523355) kills cancer cells during mitotic arrest, causes a dose-dependent increase of cells with 4N DNA content.
Litronesib ((R)-Litronesib, LY2523355) also inhibits Eg5 localization to the mitotic spindle.
Litronesib ((R)-Litronesib, LY2523355) shows potent, broad-spectrum anticancer activity in vitro at low concentrations (IC50 values ranging from 0.4 nM to14 nM) against a panel of 21 cancer cell lines, SAC has an essential role in mitotic arrest and subsequent cell killing by Litronesib.
Litronesib ((R)-Litronesib, LY2523355) has broad-spectrum antitumor activity in vivo, which is is associated with mitotic arrest and death of cancer cells.
