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Chemical Structure : Lucerastat
Catalog No.: PC-61429Not For Human Use, Lab Use Only.
A galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM).
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A galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM); prevents glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders, without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50>1 mM); shows potential as substrate reduction therapy for glycolipid storage disorders such as Gaucher disease and Fabry disease.
Other Indication
Phase 1 Clinical
| M.Wt | 219.281 | |
| Formula | C10H21NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14.
2. Andersson U, et al. Biochem Pharmacol. 2000 Apr 1;59(7):821-9.
3. Kasperzyk JL, et al. J Neurochem. 2004 May;89(3):645-53.
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