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Chemical Structure : Lumiracoxib
CAS No.: 220991-20-8
Catalog No.: PC-20195Not For Human Use, Lab Use Only.
Lumiracoxib (COX-189) is a highly selective COX-2 inhibitor with IC50 of 0.14 uM in COX-2-expressing dermal fibroblasts, inhibits purified COX-2 with Ki of 0.06 uM, 50-fold selectivity over COX-1 (Ki=3 uM).
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|---|---|---|---|
| 25 mg | $168 | In stock | |
| 100 mg | $388 | In stock | |
| 250 mg | $558 | In stock | |
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Lumiracoxib (COX-189) is a highly selective COX-2 inhibitor with IC50 of 0.14 uM in COX-2-expressing dermal fibroblasts, inhibits purified COX-2 with Ki of 0.06 uM, 50-fold selectivity over COX-1 (Ki=3 uM).
Lumiracoxib shows no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).
Lumiracoxib shows IC50 of 0.13 uM a human whole blood assay, 515 fold over COX-1.
Ex vivo, lumiracoxib inhibited COX-2-derived production of prostaglandin E(2) (PGE(2)) in the lipopolysaccharide-stimulated rat air pouch with an ID(50) value of 0.24 mg kg(-1).
Lumiracoxib showed dose-dependent effect in rat models of hyperalgesia, oedema, pyresis and arthritis.
| M.Wt | 293.72 | |
| Formula | C15H13ClFNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid |
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1. Ronald Esser, et al. Br J Pharmacol. 2005 Feb;144(4):538-50.
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