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Chemical Structure : Lurbinectedin
CAS No.: 497871-47-3
Catalog No.: PC-38616Not For Human Use, Lab Use Only.
Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 500 ug | $558 | In stock | |
| 1 mg | $958 | In stock | |
| 2 mg | $1580 | In stock | |
| 5 mg | Get quote |
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Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
Lurbinectedin (PM01183) inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer.
Lurbinectedin (PM01183) attenuates nucleotide excision repair (NER) and shows activity toward platinum-resistant cells.
Lurbinectedin (PM01183) inactivates EWS-FLI1 transcription factor by redistributing the protein within the nucleus to the nucleolus.
| M.Wt | 784.881 | |
| Formula | C41H44N4O10S | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Vidal A, et al. Clin Cancer Res. 2012 Oct 1;18(19):5399-411.
2. Soares DG, et al. Mol Cancer Ther. 2011 Aug;10(8):1481-9.
3. Elez ME, et al. Clin Cancer Res. 2014 Apr 15;20(8):2205-14.
4. Harlow ML, et al. Cancer Res. 2016 Nov 15;76(22):6657-6668.
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