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Chemical Structure : Luvadaxistat
Catalog No.: PC-20902Not For Human Use, Lab Use Only.
TAK-831 (Luvadaxistat, NBI-1065844) is a highly potent, selective D-amino acid oxidase (DAAO) inhibitor with IC50 of 14 nM against human recombinant DAAO enzyme.
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TAK-831 (Luvadaxistat, NBI-1065844) is a highly potent, selective D-amino acid oxidase (DAAO) inhibitor with IC50 of 14 nM against human recombinant DAAO enzyme.
TAK-831 (Luvadaxistat) inhibits the formation of H2O2, the co-product of D-serine catalysis, with an IC50 of 12 nM, in a cellular assay using CHO cells expressing recombinant human DAAO.
TAK-831 (Luvadaxistat) inhibits H2O2 formation with IC50 of 5.1 nM in CHO cells expressing recombinant mouse DAAO.
TAK-831 (Luvadaxistat) shows very little off-target activity when profiled in a comprehensive selectivity panel of enzyme and radioactivity binding.
TAK-831 (Luvadaxistat) caused a dose- and exposure-dependent blockade of PGM019260 binding in the cerebellum with ED50 of 0.93 mg/kg in enzyme occupancy studies in mice.
TAK-831 (Luvadaxistat) (3 mg/kg p.o.) significantly reverses a poly(I:C)-induced deficit, improves social behavior in the SI test in BALB/c animals.
| M.Wt | 284.24 | |
| Formula | C13H11F3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fradley R, et al. Neurochem Res. 2023 Jun 8. doi: 10.1007/s11064-023-03956-2.
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